PECAM1 (platelet and endothelial cell adhesion molecule 1), a member of the Ig (immunoglobulin) superfamily, is a multifunctional vascular cell adhesion and signaling molecule. It is a surface molecule found on circulating leukocytes, endothelial cells, and platelets. It is a glycoprotein with a molecular weight of 130kDa, and is composed of a single-chain of six Ig-like extracellular homology domains (total 574-residues), a transmembrane portion of 19 residues, and a cytoplasmic tail containing 118 amino acids. This gene is localized to human chromosome 17q23, and is a 75kb gene composed of 16 exons.
[1][2]Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0kDa by SDS-PAGE analysis under reducing conditions.