N -溴代丁二酰亚胺，N-Bromosuccinimide [NBS]；ReagentPlus®, 99%

N-Bromosuccinimide (NBS) is an organic compound commonly used as a brominating agent in organic synthesis. It is a convenient source of bromine radicals. It is used in radical bromination of allylic and benzylic positions. Additionally, NBS is also used as a reagent in electrophilic addition and electrophilic substitution reactions in organic chemistry.

 

N-Bromosuccinimide can be used as a reagent:      

• In the Wohl-Ziegler reaction (bromination at allylic positions via a radical pathway).      
• To synthesize benzils and aliphatic 1,2-diketones from hydrobenzoins and 1,2-diols in the presence of CCl₄ as a solvent.      
• To prepare tricyclic azepino[4,5-b]indoles from indole-β-enaminoesters or β-enaminones via Pictet–Spengler cyclization.
• To synthesize acylsilanes via oxidative hydrolysis of 2-silyl-1,3-dithianes.

多功能溴化剂。用于色氨酸的氧化反应，但酪氨酸、组氨酸和甲硫氨酸残基被氧化的程度可能较低。也可用于核糖体巯基的改性。

 

NBS is an easier and safer brominating agent to handle than bromine.

 

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