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DL-氨基谷氨酰胺 [氨鲁米特],DL-Aminoglutethimide;≥98% (TLC)

别名:3-(对氨基苯基)-3-乙基哌啶-2,6-二酮,3-(4-氨基苯基)-3-乙基-2,6-哌啶二酮;3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione, 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

Empirical Formula (Hill Notation): C13H16N2O2 CAS号: 125-84-8 分子量: 232.28 EC 号: 204-756-4 MDL编号: MFCD00010122 PubChem化学物质编号: 24278142 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A9657
CAS号: 125-84-8
MDL号: MFCD00010122
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¥1,750.00

说明

应用

DL-Aminoglutethimide has been used:
  • as a steroid synthesis inhibitor to study its effects on steroid synthesis in amphibian Xenopus laevis oocytes[1]
  • as an adrenostatic compound to study its effects on full form Enhanced green fluorescent protein (EGFP) andproopiomelanocortin (POMC) expression in the anterior domain of zebrafish pituitary corticotrophs[2]
  • as an inhibitor of steroidogenic enzymes to study its effects on estrogen receptor (ER) mRNA levels in mouse tumor leydig cell line [3]

生化/生理作用

DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).
 

特点和优势

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

生物来源

synthetic

质量水平

测定

≥98% (TLC)

形式

powder or crystals

颜色

white

mp

152-154 °C (lit.)

溶解性

H2O: slightly soluble 0.2 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.2 mg/mL
0.1 M HCl: soluble
acetonitrile: soluble
methanol: soluble

创始人

Novartis

储存温度

room temp

SMILES string

CCC1(CCC(=O)NC1=O)c2ccc(N)cc2

InChI

1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)

InChI key

ROBVIMPUHSLWNV-UHFFFAOYSA-N

Gene Information

human ... CYP11A1(1583) , CYP17A1(1586) , CYP19A1(1588)
rat ... Cyp19a1(25147)

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
商品标签 [tags]