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D-(+)-半乳糖胺盐酸盐,D-(+)-Galactosamine hydrochloride;≥99%

别名:D-(+)-氨基半乳糖盐酸盐;2-氨基-2-脱氧-D-半乳糖 盐酸盐;D-软骨糖胺盐酸盐;D-半乳糖胺盐酸盐;D-氨基半乳糖;2-Amino-2-deoxy-D-galactopyranose hydrochloride;D-Chondrosamine hydrochloride

Empirical Formula (Hill Notation): C6H13NO5 · HCl CAS号: 1772-03-8 分子量: 215.63 Beilstein: 3697825 EC 号: 217-198-1 MDL编号: MFCD00135830 PubChem化学物质编号: 24894912 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): G0500
CAS号: 1772-03-8
MDL号: MFCD00135830
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¥1,360.00

说明

D-半乳糖胺(D-GalN)是一种特别在肝细胞中代谢的特异性肝毒性物质。它是一种源自半乳糖的6碳氨基糖。
半乳糖胺(Gal)通过坏死和凋亡诱导肝细胞死亡。它通过尿苷二磷酸己糖胺的产生阻止肝脏RNA的产生。D-氨基半乳糖降低了细胞内尿嘧啶核苷酸库,从而阻止RNA和蛋白质的产生。

一般描述

D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose.
 

应用

D-(+)-半乳糖胺(D-软骨胺)联合脂多糖(LPS)用于诱导急性肝衰竭模型(LPS/D-GALN诱导肝损伤、肝炎)的治疗研究,以寻找新药。[1]
D-(+)-Galactosamine hydrochloride has been used:
  • for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces
  • in sterile phosphate buffer saline (PBS) before the intraperitoneal injection
  • in mice for the generation of primary bone marrow-derived macrophages (BMDMs)

生化/生理作用

Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins.
 
 

属性

生物来源

shark (cartilage)

质量水平

测定

≥99%

形式

powder

technique(s)

HPLC: suitable

杂质

≤0.5% Glucosamine (HPAE)

mp

172-180  °C

溶解性

H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow

SMILES string

Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO

InChI

1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1

InChI key

CBOJBBMQJBVCMW-NQZVPSPJSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32