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重组人磷酸肌醇3-激酶p110γ,Phosphoinositide 3-kinase p110γ human [PI3K p110γ human];≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

磷酸肌醇3-激酶p110γ人;Phosphatidylinositol 3-kinase p110γ human;重组人磷酸肌醇3-激酶p110γ突变体;MDL编号: MFCD03457993 NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): P8615
MDL号: MFCD03457993
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¥8,952.22

说明

磷脂酰肌醇 3-激酶 p110γ /磷脂酰肌醇-4,5-二磷酸 3-激酶催化亚基γ (PIK3CG) 基因,在基因组 DNA 上具有 12 个跨越 43 kb 的外显子,定位于人类染色体 7q22.3。PIK3CG属于编码磷酸化磷脂酰肌醇3′-羟基的酶的基因家族。

PI 3激酶与哺乳动物细胞表面受体引发的各种细胞反应有关。抑制由IFN-γ诱导的NF-κB,AP-1和STAT1α介导的基因表达,从而抑制COX-2和NOS ll(iNOS)表达。
磷脂酰肌醇 3-激酶 p110γ 与嗜酸性粒细胞炎症的发生有关。因此,抑制PI3Kγ表达可被认为是治疗嗜酸性粒细胞相关疾病(包括哮喘)的潜在治疗方法。PIK3CG基因的敲低抑制PI3K-Akt/PKB信号通路,这对于肿瘤发生和结直肠癌的进展至关重要。基因突变与自闭症的发展有关。
PI 3激酶与哺乳动物细胞表面受体引发的各种细胞反应有关。抑制由IFN-γ诱导的NF-κB,AP-1和STAT1α介导的基因表达,从而抑制COX-2和NOS ll(iNOS)表达。

一般描述

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3.[1][2] PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.[2]
 

生化/生理作用

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma.[3] Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers.[4] Mutation in the gene is associated with the development of autistic disorder.[2]
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
 

单位定义

1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.
 

外形

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.
 
 

属性

重组

expressed in baculovirus infected insect cells

质量水平

测定

≥95% (SDS-PAGE)

形式

buffered aqueous glycerol solution

specific activity

~4.5 units/mg protein

UniProt登记号

运输

dry ice

储存温度

−70°C

Gene Information

human ... PIK3CG(5294)

 

安全信息

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

商品规格
属性名称属性值
储存温度 Storage temp.-70°C超低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32