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橄榄苦苷,Oleuropein;≥80% (HPLC)

别名:(2S,3E,4S)-3-亚乙基-2-(β-D-葡吡喃糖氧基)-3,4-二氢-5-(甲氧羰基)-2 H-吡喃-4-乙酸 2-(3,4-二羟苯基)乙酯;(2S,3E,4S)-3-Ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid 2-(3,4-dihydroxyphenyl)ethyl ester

CAS号 32619-42-4 经验分子式(希尔表示法) C25H32O13 分子量 540.51 EINECS 编号 251-129-6 MDL number MFCD16879008 PubChem Substance ID 329818929 NACRES NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): O8889
CAS号: 32619-42-4
MDL号: MFCD16879008
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¥3,412.59

说明

橄榄苦苷是橄榄油的主要酚类化合物之一,它使特级初榨橄榄油具有苦味和辛辣味。它是一种 secoiridoids 和具有油质骨架的 3-羟基酪醇酯。橄榄苦苷存在于油橄榄的油和果实中,也存在于木犀科的属中。

橄榄苦苷已用于:
作为抗癌剂,在细胞活力测定中测试其对两种乳腺癌细胞系(MCF7 和 MDA-MB-231)中不同凋亡途径调节剂的影响
作为抗氧化剂测试其对过氧化氢 (H2O2) 诱导的人成纤维细胞系过早衰老的影响
在两种卵巢细胞系(A2780S 和 A2780/CP 细胞系)中测试其对细胞活力、顺铂耐药性和凋亡的抗癌特性
作为模型抗氧化剂分析 2,2-diphenyl-1-picrylhydrazyl (DPPH) 在不同溶剂中的猝灭活性

橄榄苦苷具有抗氧化、抗炎、抗菌、抗病毒、降血糖、降血脂、神经保护和抗衰老等多种药理作用。在体外研究中,它已显示出对支原体菌株的抗支原体活性。
橄榄油的酚类成分。有助于橄榄油的抗癌特性。橄榄苦苷及其代谢物羟基酪醇可抑制癌细胞增殖和
诱导癌细胞凋亡。

一般描述

Oleuropein is one of the main phenolic compounds of olive oil, which gives a bitter and pungent taste to the extra-virgin olive oil. It is a type of secoiridoids and an ester of 3-Hydroxytyrosol with an oleosidic skeleton. Oleuropein is found in the oil and fruits of Olea europaea and also in genera belonging to the Oleaceae family.
 

应用

Oleuropein has been used:
  • as an anticancer agent to test its effect on different apoptotic pathway regulators in two breast cancer cell lines (MCF7 and MDA-MB-231) in cell viability assay
  • as an antioxidant to test its effect on the hydrogen peroxide (H2O2)-induced premature senescence in human fibroblast cell lines
  • to test its anticancer properties on the cell viability, cisplatin resistance, and apoptosis in two ovarian cell lines (A2780S and A2780/CP cell lines)
  • as a model antioxidant to analyze the quenching activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) in different solvents

生化/生理作用

Oleuropein has many pharmacological benefits with its antioxidant, anti-inflammatory, antimicrobial, antiviral, hypoglycemic, hypolipidemic, neuroprotective, and anti-aging effects. It has shown antimycoplasmal activity against Mycoplasma strains in in vitro studies.
Phenolic constituent of olive oil. Contributes to anticancer properties of olive oil. Oleuropein and its metabolite, hydroxytyrosol, inhibit the rate of cancer cell proliferation and
induce cancer cell apoptosis.
 
 

属性

质量水平

100

描述

Synthetic

测定

≥80% (HPLC)

形式

powder

储存温度

room temp

SMILES string

COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)\C(=C\C)[C@@H]1CC(=O)OCCc3ccc(O)c(O)c3

InChI

1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18+,20+,21-,22+,24-,25-/m0/s1

InChI key

RFWGABANNQMHMZ-ZCHJGGQASA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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