General description
Glimepiride is a class II biopharmaceutical second-generation sulfonylurea.
Application
Glimepiride has been used:
• as a hypoglycemic drug to test its anti-diabetic functionality in human umbilical vein cells (HUVECs)
• as a sulfonylurea ATP-sensitive potassium channel (KATP) channel inhibitor in breast cancer MDA-MB-231 cells
• in glucose-stimulated insulin secretion (GSIS) assays of neonatal islet-like cell clusters (NICCs) to test its effect on insulin secretion
格列美脲目前可用于治疗 2 型糖尿病。
Biochem/physiol Actions
Glimepiride reduces blood glucose levels by stimulating the pancreatic β cells to secrete insulin hormone. It interacts with a 65-kD protein associated with β cells.
格列美脲是一种有效的心肌梗死 KATP 通道阻断剂,被吡那地尔激活,IC50 值为 6.8 nM。