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黄素腺嘌呤二核苷酸二钠盐水合物,Flavin adenine dinucleotide disodium salt hydrate [FAD-Na2];≥95% (HPLC), powder

别名:FAD,黄素腺嘌呤二核苷酸二钠盐水合物,核黄素-5'-腺苷二磷酸 二钠盐, FAD-Na2, FAD, Riboflavin 5′-adenosine diphosphate disodium salt

Empirical Formula (Hill Notation): C27H31N9Na2O15P2 · xH2O CAS号: 84366-81-4 分子量: 829.51 (anhydrous basis) Beilstein: 5326842 MDL编号: MFCD08277021 PubChem化学物质编号: 24894909 NACRES: NA.51
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): F6625
CAS号: 84366-81-4
MDL号: MFCD08277021
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¥773.90

说明

黄素腺嘌呤二核苷酸二钠盐水合物(FAD-Na2)是一种含腺嘌呤的酶促氧化还原辅因子。FAD也称为黄素辅因子,是生命系统中关键的电子转运蛋白。它们催化数个1-2电子氧化还原反应。例如,脂肪酸的β-氧化在FAD作为辅因子的存在下发生。FAD是维生素B12(核黄素)的两种活性辅酶之一。FAD在水溶液中的激发态寿命明显短于其类似物黄素单核苷酸。

一般描述

Flavin adenine dinucleotide disodium salt hydrate (FAD-Na2) is an adenine-containing enzymatic redox cofactor. Also known as flavin cofactors, FAD is critical electron transporter in living systems. They catalyze several 1-2 electron redox reactions. e.g., β-oxidation of fatty acids occurs in the presence of FAD as a cofactor. FAD is one of the two active coenzymes of vitamin B12(riboflavin). FAD displays a significantly shorter excited state lifetime in aqueous solutions than its analog, flavin mononucleotide.
 

应用

黄素腺嘌呤二核苷酸(FAD)被用作黄素蛋白的氧化还原辅因子(电子载体),这些黄素蛋白包括琥珀酸脱氢酶(复合物)、α-酮戊二酸脱氢酶、凋亡诱导因子2(AIF-M2,AMID)、叶酸/FAD依赖性tRNA甲基转移酶和N-羟基化黄素蛋白单加氧酶。 FAD是丙酮酸脱氢酶复合物的组分。
FAD is used to remove reactive oxygen species (ROS) from mammalian cells. The fluorescence mechanism of FAD is used to study energy-dependent intramitochondrial redox potential. FAD is used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes.
 
 

属性

质量水平

测定

≥95% (HPLC)

形式

powder

颜色

yellow to orange-brown

储存温度

−20°C

SMILES string

[Na+].[Na+].[H]O[H].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n5cnc6c(N)ncnc56)c2cc1C

InChI

1S/C27H33N9O15P2.2Na.H2O/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;;1H2/q;2*+1;/p-2/t14-,15+,16+,19-,20+,21+,26+;;;/m0.../s1

InChI key

GXTPHHZYFMAGLX-UJXBNFGUSA-L

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16