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卡维地洛,Carvedilol;Pharmaceutical Secondary Standard; Certified Reference Material

别名:1-(9H-咔唑-4-氧基)-3-[2-(2-甲氧基苯氧基)乙基氨基]-2-丙醇;卡维地罗;1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol;BM-14190

Empirical Formula (Hill Notation): C24H26N2O4 CAS号: 72956-09-3 分子量: 406.47 MDL编号: MFCD00864692 PubChem化学物质编号: 329823261 NACRES: NA.24
货号(SKU): PHR1265
CAS号: 72956-09-3
MDL号: MFCD00864692
增值税发票 √ 技术支持 √ 质量保障 √ 电话:13910327035
¥1,260.00

说明

卡维地洛是一种亲脂性的β1-和β2-肾上腺素受体拮抗剂,具有抗氧化和抗增生性质。 它被处方为治疗高血压,稳定的心绞痛,心肌梗塞后伴有左心室功能障碍的药物,以及症状性慢性心力衰竭的所有程度。
卡维地洛可以用作通过各种色谱技术在药物制剂和血清样品中测定分析物的药物参考标准。
卡维地洛是一种非选择性的β-肾上腺素能阻断剂,具有α1阻断活性。 卡维丝酚专门用于治疗心力衰竭和高血压。 已显示它可以改善左心室射血分数,并可能降低死亡率。

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Carvedilol is a lipophilic β1- and β2-adrenoreceptor antagonist that exhibits antioxidant and antiproliferative properties. It is prescribed as a medicine for the treatment of hypertension, stable angina pectoris, post myocardial infarction with left ventricular dysfunction and all degrees of symptomatic chronic heart failure.
 

应用

Carvedilol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.
 

注意

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
 

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAA9063 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0001427
traceable to USP 1096622

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

InChI key

OGHNVEJMJSYVRP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

 

安全信息

象形图

Environment

危险声明

预防措施声明

危险分类

Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
商品标签 [tags]