过滤
关闭导航

α-酮戊二酸,α-Ketoglutaric acid [α-KG];BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98.5%

别名:2-氧代戊二酸;2-氧化戊二酸; 2-Oxoglutaric acid;2-Oxopentanedioic acid

线性分子式: HOOCCH2CH2COCOOH CAS号: 328-50-7 分子量: 146.10 Beilstein: 1705689 EC 号: 206-330-3 MDL编号: MFCD00004165 PubChem化学物质编号: 24896202 NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): K1128
CAS号: 328-50-7
MDL号: MFCD00004165
增值税发票 √ 技术支持 √ 质量保障 √ 电话:13910327035
¥573.68

说明

一般描述

Alpha-ketoglutarate (αKG), a vital intermediate in the tricarboxylic acid (TCA)/Krebs cycle, is located between succinyl-CoA and isocitrate.[1]
 

应用

α-Ketoglutaric acid has been used:
  • as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis[1]
  • for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms[2]
  • as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)[3]

生化/生理作用

Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine.[4] It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle.[1] It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism.[4] In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects.[1] This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.
 
 

属性

产品线

BioReagent

质量水平

测定

≥98.5% NaOH basis (titration)

形式

powder or crystals

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

溶解性

water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless

储存温度

2-8°C

SMILES string

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

 

安全信息

象形图

Corrosion

警示用语:

Danger

危险声明

预防措施声明

危险分类

Eye Dam. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
商品标签 [tags]