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阿托品,Atropine;≥99% (TLC), powder

别名:龙葵碱;莨菪碱;(8-甲基-8-氮杂双环3.2.1辛-3-基) endo-(+/-)-α-(羟甲基)苯乙酸酯;endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo3.2.1oct-3-yl ester, Hyoscyamine, Tropine tropate

Empirical Formula (Hill Notation): C17H23NO3 CAS号: 51-55-8 分子量: 289.37 Beilstein/REAXYS Number: 91260 EC 号: 200-104-8 MDL编号: MFCD00022622 PubChem化学物质编号: 24890401 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A0132
CAS号: 51-55-8
MDL号: MFCD00022622
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₹ 7,182.39

说明

一般描述

Atropine, a belladonna alkaloid, is an anti-muscarinic drug. It is extracted from Atropa belladonna. Atropine is an anticholinergic agent, which is linked to passive mydriasis. It blocks acetylcholine receptors in brain and has hallucinogenic effects. Atropine eye drops are used to treat uveitis and early amblyopia. It is also used to treat nerve agents.
 

应用

Atropine has been used:
  • as a tastant to analyse the bitter taste perception in Drosophila larvae
  • as a muscarinic acetylcholine autoreceptors (mAChRs) antagonist to investigate the involvement of individual mAChR subtypes in the control of synapse elimination
  • to investigate the pathways of serotonin (5-HT) action in zebrafish hearts
Atropine has been used to study it′s in vitro cytotoxicity, antiviral and antimicrobial activities. It has also used to antagonize acetylcholine induced K+ current.
 

包装

1, 5, 25, 100 g in glass bottle
 

生化/生理作用

Atropine is used to treat myopia and ocular axial elongation in Asian children. Small dosage of atropine is used to slow down the heart rate.
位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。
 

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

重悬

Solutions stable for several days at 4 °C.
 

属性

测定

≥99% (TLC)

形式

powder

颜色

white

溶解性

H2O: 2 mg/mL
dilute aqueous acid: soluble
ethanol: soluble

创始人

Pfizer

SMILES string

CN1C@H2CCC@@H1CC@@H(C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

InChI key

RKUNBYITZUJHSG-SPUOUPEWSA-N

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), LOC730413(730413)
mouse ... Chrm1(12669)
rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260), Drd2(24318), Htr1a(24473)

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

个人防护装备

Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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