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褪黑素,Melatonin;≥98% (HPLC)

别名:褪黑素标准品,退黑素,N-乙酰-5-甲氧基色胺,松果体素,褪色素,褪黑色素,N-乙酰基-5-甲氧基色胺,N-Acetyl-5-methoxytryptamine;Melatonin - CAS 73-31-4 - Calbiochem;5-Methoxy-N-acetyltryptamine

CAS号 73-31-4 经验分子式(希尔表示法) C13H16N2O2 分子量 232.28 MDL number MFCD00005655
货号(SKU): M0176
CAS号: 73-31-4
MDL号: MFCD00005655
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产品描述

一种被认为是光周期哺乳动物中光诱导抗性腺激素活性的调节剂的激素。对抗足叶乙甙对骨髓细胞的凋亡作用。褪黑素受体与G蛋白系统偶联。抑制大鼠小脑一氧化氮合酶(NOS)。
一种被认为是光周期哺乳动物中光诱导抗性腺激素活性介体的激素。对抗足叶乙甙对骨髓细胞的凋亡作用。褪黑素受体与G蛋白系统偶联。具有抗氧化性能。对Aβ肽具有神经保护作用。抑制大鼠小脑一氧化氮合酶(NOS)。也可作为过氧亚硝酸盐清除剂。

General description

A hormone that has been postulated as being a mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Inhibits rat cerebellar nitric oxide synthase (NOS).

A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Exhibits antioxidant properties. Has neuroprotective effects against Aβ peptides. Inhibits rat cerebellar nitric oxide synthase (NOS). Also acts as a peroxynitrite scavenger.

Biochem/physiol Actions

Cell permeable: no

Primary Target
rat NOS

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pappolla, M.A., et al. 2002. J. Pineal Res.32, 135.
Reiter, R.J., and Tan, D.X. 2002. Ann. N.Y. Acad. Sci.957, 341.
Cuzzocrea, S., et al. 1998. J. Pineal Res. 25, 24.
Maestroni, G.J., et al. 1994. Cancer Res. 54, 2429.
Pozo, D., et al. 1994. Life Sciences55, PL455.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
storage condition  OK to freeze
 protect from light
storage conditions:  +2C to +8C
color  white to slightly yellow
solubility  methanol: 50 mg/mL
shipped in  ambient
InChI  1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChI key  DRLFMBDRBRZALE-UHFFFAOYSA-N


安全信息

个人防护装备 Eyeshields, Gloves, type N95 (US)
RIDADR NONH for all modes of transport
WGK德国 2
RTECS AC5955000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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